3) If you created a line of endothelial cells which constitutively expressed tel

Question

3) If you created a line of endothelial cells which constitutively expressed telomerase (EndoTM+) what result would you not expect to find:

A) After many rounds of cell division, EndoTM+ cells would have reduced senescence associated -galactosidase (a marker of cell aging) activity than cells which do not constitutively express telomerase.

B) After many rounds of cell division, EndoTM+ cells would have longer telomeres than cells which do not constitutively express telomerase.

C) Cells that did not constitutively express telomerase would have a lower Hayflick limit than EndoTM+ cells.

D) EndoTM+ cells would have a longer lifespan than cells that did not express telomerase constitutively

E) All of these results would likely be observed.

Explanation / Answer

Answer: E) All of these results would likely be observed.

After many rounds of cell division, EndoTM+ cells would have reduced senescence associated -galactosidase (a marker of cell aging) activity than cells which do not constitutively express telomerase. After many rounds of cell division, EndoTM+ cells would have longer telomeres than cells which do not constitutively express telomerase. Cells that did not constitutively express telomerase would have a lower Hayflick limit than EndoTM+ cells. EndoTM+ cells would have a longer lifespan than cells that did not express telomerase constitutively.

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