Determine if the dosage ordered is safe. If the order is safe, then find the amo
ID: 321519 • Letter: D
Question
Determine if the dosage ordered is safe. If the order is safe, then find the amount to administer. Assume the patient has impaired renal function.
The patient: 82-year-old female, 4 ft 10 in. tall, 102 lb, CLCR of 26 mL/min. Patient is within ideal weight range.
Ordered: Acyclovir sodium (Zovirax®) 450 mg IV q12h infused over 1 h
On hand: Zovirax® for injection, 50 mg/mL when reconstituted
According to the package insert, the recommended dose for this diagnosis for patients with normal renal function is 10 mg/kg q8h. The dose is adjusted as follows for patients with impaired renal function: for creatinine clearance over 50 mL/min, 100% of the recommended dose every 8 h; from 25 to 50 mL/min, 100% of the recommended dose every 12 h; from 10 to 25 mL/min, 100% of the recommended dose every 24 h; for 0 to 10 mL/min, 50% of the recommended dose every 24 h.
Is the dose safe or unsafe?
A=__mL
Explanation / Answer
According to the package insert, the recommended dose for this diagnosis for patients with normal renal function is 10 mg/kg q8h. The dose is adjusted as follows for patients with impaired renal function: for creatinine clearance over 50 mL/min, 100% of the recommended dose every 8 h; from 25 to 50 mL/min, 100% of the recommended dose every 12 h; from 10 to 25 mL/min, 100% of the recommended dose every 24 h; for 0 to 10 mL/min, 50% of the recommended dose every 24 h.
Is the dose safe or unsafe?
ANSWER : SAFE DOSE
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ANSWER :
AMOUNT TO ADMINSTER = 9 mL
=(Ordered /On hand ) X10 mL =
=(450 / 500) *10 = 9 ml
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