Q1 A group of Ethiopians were assayed for CCR5-del32 deletion polymorphism. 247

Question

Q1 A group of Ethiopians were assayed for CCR5-del32 deletion polymorphism. 247 were +/+, 69 were +/del32, and 11 were del32/del32. Are the observed data significantly different from HWE? If not, what might explain the pattern.

Q2 Industrial melanism refers to the dark pigmentation that evolved in some insects giving them protective coloration on vegetation darkened by soot in heavily industrialized areas prior to air pollution regulation. Assume that in one heavily polluted area near Birmingham, England in 1956, 79% of the moths of the species Biston betularia were black due to the presence of a dominant gene for melanism. Estimate the frequency of the dominant allele in this population, and the proportion of black moths that are heterozygous.

Explanation / Answer

1)

Frequency +/+ (p) = 247/327 = 0.755

Frequency of +/ del 32 (pq) = 69/327 = 0.211

Frequency of del 32 / del 32 (q) = 11/327 = 0.033

To know whether the data is in HWE (p +q)2 = p2 + 2pq +q2=1

Substituting the above obtained frequencies in the equation,

then (0.755)2 +2 (0.211) + (0.033)2 = 0.57 + 0.42 + 0.001 = 0.991

The allele frequencies are very close to HWE and have very minute variation.

2)

79% population contain dominant Black color (BB). The allele frequency is B = 0.79. Allele frequency for b is 0.21. The allele frequency for Bb is 0.33. The allele frequencies are in HWE = 0.62 + 0.33 + 0.04 = 0.99.

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