A study on mixed species cloning was conducted to test if a non-human donor spec
ID: 3221210 • Letter: A
Question
A study on mixed species cloning was conducted to test if a non-human donor species could provide an egg for insertion of human dna for the clonal production of human stem cells. So an experiment was conducted in which unfertilized eggs were obtained from two species (pigs and sheep; 3 individuals of each species) and their nucleus was replaced with the nucleus from one of 12 human donors chosen at random. Four eggs from each individual pig or sheep were harvested and their nuclei removed and replaced with human donor nuclei; two from one human and two from another. After the eggs developed, an embryonic stem cell was obtained from each embryo and the number of mutations in a specific gene sequence was determined. Is there a significant difference in the number of mutations between stem cells derived from pigs vs. sheep? How much variation in the number of mutations can be attributed to differences among humans? [YOU MAY ASSUME THAT ALL ASSUMPTIONS ARE MET FOR THIS QUESTION] A study on mixed species cloning was conducted to test if a non-human donor species could provide an egg for insertion of human dna for the clonal production of human stem cells. So an experiment was conducted in which unfertilized eggs were obtained from two species (pigs and sheep; 3 individuals of each species) and their nucleus was replaced with the nucleus from one of 12 human donors chosen at random. Four eggs from each individual pig or sheep were harvested and their nuclei removed and replaced with human donor nuclei; two from one human and two from another. After the eggs developed, an embryonic stem cell was obtained from each embryo and the number of mutations in a specific gene sequence was determined. Is there a significant difference in the number of mutations between stem cells derived from pigs vs. sheep? How much variation in the number of mutations can be attributed to differences among humans? [YOU MAY ASSUME THAT ALL ASSUMPTIONS ARE MET FOR THIS QUESTION]
species Human # Mutations Pig Pi 11 15 12 14 12 F ta 56 31122256568 13-14 4 7 7 sos-1s-14-11 34 D 1-122334-4556677889_9-10-10-11 001-122 Hd | ec vi 1 1 1 1 2 2 2 2 3 3 3 3 1 1 1 1 2 2 2 2 3 3 33 sp di Pi Pi Pit Pit Pi Pi Pi-Pi Pi-She-She-She-She-Sh Sh Sh Sh Sh Sh Sh Sh
Explanation / Answer
Answer:
Analysis of variance (ANOVA) is a statistical method used to analyze the differences among group means and dicrepancies between them . Here we have to test whether there is a significant difference in the number of mutations between stem cells derived from pigs. Hence ANOVA would do the work
For the question how much variation in the number of mutations can be attributed to differences among humans.
Using ANOVA, we can measure this by dividing the sum of squares between groups by the sum of squares total.
TY!
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