Concentration profiles within gradient scaffold systems from a diffusion model s

Question

Concentration profiles within gradient scaffold systems from a diffusion model simulation. (A) (B) (C) Concentration profiles within the scaffold with PLGA microspheres loaded different doses of PDGF-BB (2, 20, 200 ng for A, B and C, respectively) predicted from a diffusion model. The color bar is in units of ng ml^-1 and is constant for all images. Insets show concentration distributions at high scale. All systems result in the same profile shape but different magnitude. Location (z = 0) is the distal-gradient layer of the scaffold and distance (z = 4 mm) is the scaffold-tissue - interface. Magnitude of the gradient for all cases (1, 10 and 100 ugml^-1) at the tissue interface. The inset shows 2 and 20 ng cases at a higher scale. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

Explanation / Answer

The color bar to the right of the plot shows the color that has been used to represent the concentration. The scaffold contains different doses of PDGF-BB within PLGA microspheres. The growth factor (PDGF) will gradually diffuse out of the microspheres throughout the scaffold. Over a period of time, the growth factor will come to exist in a concentration gradient, with highest concentrations in the core of the scaffold and gradually decreasing as a function of distance from the center. The graphs depict this information. On any point of time, the concentration of the growth factor at a particular distance within the scaffold has been plotted. The three graphs (A-C) compare the concentration gradients that develop over time when three different doses of the growth factor were loaded within the PLGA microspheres.

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