2. (medicine) l40 total points) In one of the largest and most famous public hea
ID: 3241817 • Letter: 2
Question
2. (medicine) l40 total points) In one of the largest and most famous public health experiments ever conducted, in 1954 a randomized controlled trial was run to see whether a vaccine developed by a doctor named Jonas Salk was effective in preventing paralytic polio. A total of 401,974 children, chosen to be representative of those who might be susceptible to the disease, were randomized to two groups: 200,745 children were injected with a harmless saline solution and the other 201,229 children were injected with Salk's vaccine. (a) What was the point of giving saline solution to the children who didn't get the vaccine? Explain briefly. 15 pointsExplanation / Answer
Answer:
What was the point of giving saline to children who didnt get the vaccine?
Answer: Only Saline was administered as a control to rule out the effect of other variables that can impact the study.
Would it have been possible to run the experiment in a double-blinded fashion.
Answer: In the double blinded experiment neither the subject nor the experimenter knows the condition to which subject belongs to. It is not always possible to run experiments in a fully (double) blinded fashion. In this case it would have been possible to run the experiment in a double blinded fashion by designing the experiment in such a way so that neither subject nor administrator (diganostic personnel) could know which subject received the vaccination. For this codes numbers could be assigned to injection vials.
Sample 1 Sample 2 Size 201229 200745 n #Successes 33 115 x Proportion 0.0002 0.0006 p-hatRelated Questions
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