3. (12 pts) A study was performed to determine the risk of coronary heart diseas
ID: 3251998 • Letter: 3
Question
3. (12 pts) A study was performed to determine the risk of coronary heart disease (CHD) in individuals with hypertension. 1,387 men between the ages of 40 to 59 with no previous CHD, were categorized as normal (no hypertension), borderline hypertension or definite hypertension. These men were followed for six years and the incidence of new CHD was recorded. There were 556 men with normal blood pressure and of those, 23 developed CHD. There were 532 men with borderline hypertension and of those, 38 developed CHD. There were 299 with definite hypertension and of those, 37 developed CHD.
a. (2 pts) What type of study is this?
b. (4 pts) Construct a 2 X 3 table for these data
c. (4 pts) Calculate the appropriate measure of association between borderline hypertension and CHD and between definite hypertension and CHD. Use the risk seen in the normal (no hypertension) group as your reference and compare the remaining two groups to the normal group.
d. (2 pts) Interpret one of the numbers you calculated in part c.
Explanation / Answer
Part-a
This is cohort study as 1387 men between ages of 40-59 with no previous CHD were followed for size years and occurrence of CHD is noted.
Part-B
2X3 table is as follows:
Hypertension
CHD
Normal
borderline
Definite
Total
Yes
23
38
37
98
No
533
494
262
1289
Total
556
532
299
1387
Part-C
Odds ratio of CHD for borderline versus definite hypertension=(38*262)/(37*494)=0.54
Risk of CHD to normal group=23/556= 0.04
Risk of CHD to borderline group=38/494=0.07
Risk of CHD to Definite group=37/299=0.12
Part-D
So , odds of CHD for borderline hypertension groups is 0.54 times lower than definite hypertension group.
Hypertension
CHD
Normal
borderline
Definite
Total
Yes
23
38
37
98
No
533
494
262
1289
Total
556
532
299
1387
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