5. Researchers are interested in the relationship between family history of Alzh
ID: 3258450 • Letter: 5
Question
5. Researchers are interested in the relationship between family history of Alzheimer’s disease and early onset of senile dementia. The study design team decides that they will recruit patients from their database based on their performance on the Mini-Mental State Examination (MMSE). Those that meet the threshold for determination of the outcome will be actively recruited, and frequency matched to two controls with normal memory performance on the MMSE. Exposure history based on a family history background check will be recorded. The following table represents a hypothetical result from the experiment. Dementia (MMSE<24) No Dementia Present (MMSE>24) Family History Present 121 232 No Family History Present 220 450 Total 341 682 A) What kind of study is being conducted? B) Calculate the appropriate risk measure to determine the difference in risk for early onset of senile dementia based on exposure status.
Explanation / Answer
a) The study is to test the relation between the association of the family history of Alzheimer's disease and early onset of senile dementia.
B)
Null Hypothesis: There is no association between family history of Alzheimer's disease and early onset of senile dementia.
Alternative Hypothesis: There is association between family history of Alzheimer's disease and early onset of senile dementia.
The estimated p-value of Chi-Square=0.2163 at (2-1)(2-1)=1 degree of freedom is 0.64. Hence, we can not reject the null hypothesis and conclude that there is no association between family history of Alzheimer's disease and early onset of senile dementia.
c1 c2 total r1 121 232 353 r2 220 450 670 total 341 682 1023 Oi 121 232 220 450 Ei 117.6667 235.3333 223.3333 446.6667 sum (O--Ei)^2/Ei 0.094429 0.047214 0.049751 0.024876 0.21627 critical value 3.84Related Questions
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