1) the deletion in T cells confers resistance to HIV infection. In which human p

Question

1) the deletion in T cells confers resistance to HIV infection. In which human populations is the mutation at relatively high frequency and where is it at relatively low frequency? Why isn't this mutation at higher frequency in populations with a high incidence of HIV infection and provide an explanation for a frequency of 20% in populations with no history of HIV infection? 1) the deletion in T cells confers resistance to HIV infection. In which human populations is the mutation at relatively high frequency and where is it at relatively low frequency? Why isn't this mutation at higher frequency in populations with a high incidence of HIV infection and provide an explanation for a frequency of 20% in populations with no history of HIV infection?

Explanation / Answer

1). HIV use CCR5 chemikine receptor to enter into the T cells of the host. A deletion mutation in CCR5 - delta32 allele confers resistance to HIV virus in those population carrying this allele. The distribution of this allele is at high frequency in Europian people (10%) and iceland (15%), less frequency is found in other regions excluding North.

2). The geographical genographic distribution of this mutaion is very selective, the pressure responsible for rise in allele varies greatly, this explains its uneven distribution.

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