One form of posttranscriptional modification of most eukaryotic RNA transcripts

Question

One form of posttranscriptional modification of most eukaryotic RNA transcripts is the addition of a poly-A sequence at the 3 end. The absence of a poly-A sequence leads to rapid degradation of the transcript. Poly-A sequences of various lengths are also added to many prokaryotic RNA transcripts where, instead of promoting stability, they enhance degradation. In both cases, RNA secondary structures, stabilizing proteins, or degrading enzymes interact with poly-A sequences.

Considering the activities of RNAs, what might be the general functions of 3-polyadenylation?

Check all that apply.

- regulation of introns' length - regulation of mRNA proofreading - regulation of mRNA association with different cellular components - regulation of mRNA longevity - regulation of mRNA transport to and from cellular organelles - regulation of mRNA splicing

Explanation / Answer

The general functions of 3-polyadenylation are regulation of mRNA association with different cellular components, regulation of mRNA transport to and from cellular organelles and regulation of mRNA longevity.

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