A French pharmaceutical company recently announced that its emergency contracept

Question

A French pharmaceutical company recently announced that its emergency contraception (EC) pill may be less effective in women who are overweight/obese compared to women who are normal/underweight. This announcement was prompted by a 2011 study that compared pregnancy rates in women who used levonorgestrel (LNG) or a second EC pill (UPA). Data from the article appears below and is reported as a series of counted proportions, y/m, in which y records the number who used the indicated EC drug but still later became pregnant and m is the number of women who used the indicated EC drug (i.e., the number of ‘trials’).

How does pregnancy risk differ between the two drugs (UPA vs LNG) for those women who are overweight/obese?

UPA (N= 1714) LNG (N= 1731) BMI (kg/m2) Normal/under (<25) 12/1110 15/1122 Over/obese (>25) 10/604 23/609

Explanation / Answer

Frm the data :

risk of pregancy of UPA drug for overweight/obese women : 10/604 = 0.016556

Risk of pregnancy of LNA drug for overweight/obese women : 23/609 = 0.037766

It is clear formt the data that risk is higher for the LNA drug. This can be because of the various reasons :

1. Difference in the working of the drugs

2. Different drugs have their own mechanism of absorbption , which depends on the reactivity, surface afrea extra.

As the data is small it is tough to come to some hard conculsion.

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