Adults with epilepsy are recruited into a clinical trial to compare the effect o

Question

Adults with epilepsy are recruited into a clinical trial to compare the effect of two classes of anticonvulsant drugs—enzyme-inducing and non-enzyme-inducing— on serum lipids. The outcome of interest is a new diagnosis of hyperlipidemia.

Use the output in SAS Output. Final Q4.pdf to answer the following questions.

a. What procedure was used to generate the results in SAS?

b. Is there sufficient evidence to suggest that drug class is associated with hyperlipidemia? Justify your response.

c. Are any of the independent variables included in the model categorical? If so which ones? Justify your response.

d. Are age and sex associated with hyperlipidemia? Justify your response.

Model Information Data Set Response Varlable Number of Response Levels 2 Model Optimization Technique Fisher's scoring FINAL EXAM Q4 hyperlipiderria binary logit Number of Observations Read 150 Number of Observations Used 150 Response Profile Total 1 No 125 2 Yes 25 Probability modeled is hyperlipidemia Yes' Class Level Information Class Value Varlables sex Female Male drug Inducing No Model Convergence Status Convergence criterion (GCONV-1E-8) satisfied Model Fit Statistics and Only Covariates AIC 137169 135365 SC 140.179 147.408 2 Log L 135.168 127.365 Testing Global Null Hypothesis: BETA#0 Test Likelihood Ratio Score Wald Chi-Square DF Pr > Chisq 0.0503 00557 0 0673 .8030 3 7.57153 .1492 3

Explanation / Answer

a) The results given in the image is the output from 'Proc Logistic' Procedure

b) Yes. There is sufficient evidence that drug class is associated with hyperlipidemia. The p-value in the Analysis of Maximum likelihood estimate has value equal to 0.042 which is less than 0.05. Hence we reject the null hypothesis that coefficient is zero and conclude that there is significant relationship between drug class with hyperlipidemia

c) Yes. Drug and sex are categorical variables used in the proc logistic procedure. And the base reference class is 'Inducing' and 'Male' which is clearly mentioned in the table 'Analysis of Maximum Likelihood Estimates'

d)From the p-values, which are equal to 0.1047 and 0.2951 for age and sex variable, both greater than 0.05, we can say that there is sufficient evidence that age and sex are not having significant relationship with hyperlipidemia

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