You are breeding horses and have two families that include individuals with a ra

Question

You are breeding horses and have two families that include individuals with a rare disorder that makes their bones fragile. Use the two pedigrees shown below to answer the following questions and assume that the bone phenotype has full penetrance.

(a) What is the likely mode of inheritance of the bone disorder?

(b) You breed the affected male from family 1 to the affected female from family 2 and find that their F1 progeny do not have the bone disorder. Suggest the most likely explanation for the progeny lacking the disorder.

Explanation / Answer

Answer

Penetrance is defined as the percentage of animals having a particular mutation or genotype who exhibit clinical signs or phenotype of the associated disorder or genotype

a)Inheritance is autosomal dominant characters in case full penetrance

b) For many inherited diseases, the same mutation is not always expressed in all cases who carry it, moreover, when the mutation is expressed, it is not always expressed in the same way. These findings are the basis for the concepts of penetrance and expressivity. may be the character is dominant it should have been expressed in the F1 generation . this explains why the progeny lacks disorders.

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