If you blocked IL-1 from binding to its receptor by administering an IL-1 monocl
ID: 3473394 • Letter: I
Question
If you blocked IL-1 from binding to its receptor by administering an IL-1 monoclonal antibody, which of the following would be true? Select all the correct answers. There may be more than one true statement It would likely result in an elevated setpoint temperature in the hypothalamus It would likely result in decreased symptoms in patients with periodic fever syndromes It would likely result in taking a few days longer to fight off pathogens than if IL-1 had not been blocked from binding to its receptor It would likely result in more LPS being made by the body It would likely result in fewer prostaglandin E2 (PGE2) molecules being made It would likely result in less COX-2 being made It would likely result in an elevated core body temperature It would likely result in more frequent fever seizures in people who had previously had a fever seizureExplanation / Answer
1. The cytokine IL-1 is a potent inducer of inflammation. Their transcription is activated following exposure to pathogen, damage, or danger-associated molecules.
2. Caspase-1 that cleaves pro-IL-1 into mature IL-1.
3. Secretion of cytokines induce the signals through Pattern Recognition Receptors.
4. IL-1 is produced by monocytes, macrophages, dendritic cells etc., and act on lymphocytes, bone marrow and vascular endothelium, liver and hypothalamus.
5. The PRR stimulates the above cells to induce immune/inflammatory effects such as neutrophil production, increase vascular permeability, induces acute-phase response, fever.
6. The PRR signalings also activates the innate immune responses and inflamatory stimuli -TNF-alfpha,IL-1,and IL-6.
7.The PRR singaling also induce fever (protective response, elevated body temperature), by producing COX-2 expression, which activates prostaglandin synthesis.
8. Prostaglandin acts on hypothalamus causing fever.
9. If IL-1 monoclonal antibody is used IL-1 protein do not bind to IL-1 receptor, so the above responses will not take place.
10 So the correct options are
a. It would likely results in less COX-2 being made,
b.It would results in fewer prostanglandin E2 molecules being made.
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