If you blocked PGE2 from binding to all of its PGE2 receptors, which of the foll

Question

If you blocked PGE2 from binding to all of its PGE2 receptors, which of the following would be true? There may be more than one true answer It would result in a regulated decrease in the hypothalamic setpoint temperature It would likely result in decreased symptoms in patients with periodic fever syndromes It would result in less IL-1 being made in the body It would likely result in the expression of uncoupler proteins in the hypothalamus It would likely result in taking a few days longer to fight off certain pathogens than if PGE2 had not been blocked from binding to its receptor It would likely result in increased incidences of fever seizures

Explanation / Answer

PGE2 is prostaglandin E2. It is a principal mediator of inflammation of rheumatoid arthritis and osteoarthritis. Also it functions to produce pain and fever. PGE2 is mainly involved in uterine contractions during labor. Since, the PGE 2 is being blocked from binding its PGE2 receptors, the PGE2 will not be able to fulfill its functions. Then following set of conditions could occur.

1. It would result in a regulated decrease in the hypothalamic setpoint temperature. Since its function is to increase the body temperature.

2. It would likely result in decreased symptoms in patients with periodic fever symptoms.

3.It would also result in less production of IL-1 being made in the body because IL-1 plays a role in immune system regulation and inflammatory responses.

4. It would not result in expression of uncoupler proteins because uncoupler are mainly involved in heat generation in the body.

5. Yes it would take few days longer to fight off pathogens since generation of heat i.e., fever is a clear symptom that body is fighting against some pathogen, also it ativates immune system.

6. It will not result in increased fever seizures.

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