1. If the regulatory subunit of PKA is not bound by cAMP, then the catalytic sub
ID: 3473789 • Letter: 1
Question
1. If the regulatory subunit of PKA is not bound by cAMP, then the catalytic subunit is free to phosphorylate intracellular proteins A) True B) False2. Inhibiting an extracellular signal terminator, such as acetylcholinesterase (AChE), causes a A) decrease in the target cells receptors B) divergent hormone effects C) decreases in the removal, degradation, or destruction of the hormone D) decrease in the receptor binding E) None of the above 1. If the regulatory subunit of PKA is not bound by cAMP, then the catalytic subunit is free to phosphorylate intracellular proteins A) True B) False
2. Inhibiting an extracellular signal terminator, such as acetylcholinesterase (AChE), causes a A) decrease in the target cells receptors B) divergent hormone effects C) decreases in the removal, degradation, or destruction of the hormone D) decrease in the receptor binding E) None of the above A) True B) False
2. Inhibiting an extracellular signal terminator, such as acetylcholinesterase (AChE), causes a A) decrease in the target cells receptors B) divergent hormone effects C) decreases in the removal, degradation, or destruction of the hormone D) decrease in the receptor binding E) None of the above
Explanation / Answer
1. Answer : False
Protein Kinase A (PKA) is cAMP dependent protein kinase which phosphorylates the substrate. When cAMP is bound to regulatory sub unit of PKA, then the catalytic sub unit of PKA is free to catalyze the transfer of ATP terminal phosphates to protein substrates at serine or threonine residues.
2. Answer : A) decrease in target cell receptors and C) decreases in the removal, degradation, or destruction of the neurotransmitter
Acetylcholinesterase is an extracellular signal terminator which acts by breaking down acetylcholine. When such signal terminator is inhibited, signal that is hormone or neurotransmitter will be available to signal continously. Hence more acetylcholine bind to target receptors. And also, acetylcholine builds up, due to decrease in the degradation and removal of acetylcholine by acetylcholinesterase.
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