3. Explain how my of the axonal membrane where myelin resent. Multiple sclerosis

Question

3. Explain how my of the axonal membrane where myelin resent. Multiple sclerosis (MS) is characterized by loss of myelin in the v miatter of the lateral and posterior columns of the spinal cord or along ner ve racts within the brain. Both efferent and afferent nerves can be affected. Knowing the function of myelin in sensory and motor nerves, can you predict the symptoms of MS? What specific process does the lack of myelination interfere with in the physiology of nerves? elin prevents an action tential from being generated on the area

Explanation / Answer

Myelin is basically like the resistant coating around the live electrical wires. It increases the resistance and decreases the capacitance across the cell membrane of the neurons. They block, cover the Na+ and K+ ion channels which inhibit the transmittance of electrical current across the length of the axon. They cause the action potential to jump from node of ranvier to another because of which the electrical potential travels faster. This process is called saltatory conduction- lacking in multiple sclerosis. Due to the lack of myelination the action potential is conducted slowly and causes delay in reception and action, slowing down the senses.

saltatory conduction is faster because the action potential jumps from one point to a far away point whereas in normal conduction the actional potential walks from one point to the adjacent which is why it is slower. Senses (heat, vision, smell, pain) need to travel fast- from reception to processing to signaling. MS is linked to cognitive dysfunction, lack of senses, fatigue, loss of muscluar function etc.

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