4. Endocrine Mystery Cses: exercise you will be playing the role of \"endocrine

Question

4. Endocrine Mystery Cses: exercise you will be playing the role of "endocrine detective" to solve various e mysteries. In each case you will have a victim who has suddenly fallen ill with a h of whom will give endocrin mysterious malady. You will be presented with a set of "witnesses", eac you a clue as to the nature of the illness. Other clues will come from samples that you will dend off to the lab for analysis. You will solve the mystery by providing the victim with a diagnosis Case 1: The Cold Colonel You are called upon to visit the ailing Col. Lemon. Before you see him, you speak with three witnesses who were with him when he fell ill. Witness statements Ms. Magenta: "Colonel Lemon has been hot-blooded for as long as I've known him. But I noticed that he couldn't seem to keep warm. He kept complaining about being ° cold ” Mr. Olive: "Just between you and me, I've noticed that the old chap has put on quite a bit of weight lately." Professor Purple: "The Colonel and I used to go on major expeditions together. Now he just doesn't seem to have the energy to do much of anything What are your initial thoughts about the witnesses' statements? Does one hormone come to mind that may be the cause? You see the Colonel and collect some blood to send off to the lab. The analysis comes back as follows: T3 (triiodothyronine): 50ng/dl (normal: 110-230 ng/dl) T4 (thyroxine): 1.1ug/dl (normal: 4-11 ug/dl) TSH (thyroid-stimulating hormone): 86 pU/ml (normal: 2-10 uU/ml) Analyze the results. Why are the T3 and T4 low and the TSH high? What is your final diagnosis? Explain.

Explanation / Answer

1. Increased weight , cold , lethargy point to decreased levels of THYROXINE called HYPOTHYROIDISM.

2. Lab analysis shows INCREASED TSH and DECREASED THE and T4.

3. Since T3 and T4 levels are low , they fail to exert NEGATIVE FEEDBACK EFFECT on TRH ( hypothalamus). As a result, TRP leads to the increasesd formation of TSH ( from anterior pituitary)

4. Final diagnosis is HYPOTHYROIDISM.

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