30 B. ) The orthopedic resident explained that patients like MJ with chronic kid

Question

30 B. ) The orthopedic resident explained that patients like MJ with chronic kidney disease can develop a bone disorder called renal osteodystrophy (ROD). She explained that renal disease affected not only the function of the kidneys, but also the amount of calcium in MJ's bones. The loss of calcium could lead to bone pain, bone fractures, and possibly even bone deformities. The resident admitted that MJ was the first child that she had seen with PKD who might also be developing ROD. The resident wanted to order some lab tests and X-rays, and discuss MJ's case with her attending physician before she was ready to make the diagnosis. They would review MJ's x-rays once they were ready.

How will bone cells be affected if MJ's kidney disease reduces the amount of calcium available to her bones?

a. Osteocytes begin to break down the bone extracellular matrix in order to maintain blood calcium levels. b. Osteoclasts will not be able to become osteocytes once they have surrounded themselves with extracellular matrix. c. Osteocytes revert back to osteoblasts in order to scavenge the little calcium that is available. d. Osteoblasts cannot perform bone deposition, in which they build up the bone extracellular matrix.

Explanation / Answer

d) is the correct answer as osteoblasts require calcium to lay down bone. Calcium is integral to the formation of bones. Osteoblasts take up calcium and deposit more bone. When serum calcium levels fall demineralization occurs without remineralization.

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