I need this article to be summarized in simple terms as an article summary/notes
ID: 3478240 • Letter: I
Question
I need this article to be summarized in simple terms as an article summary/notes.
Eriksson, K. -., & Lindgrde, F. (1991). Prevention of Type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise. Diabetologia, 34(12), 891-898.
From a previously reported 5-year screening programme of 6,956 47-49-year-old Malmö males, a series of 41 subjects with early-stage Type 2 (non-insulin-dependent) diabetes mellitus and 181 subjects with impaired glucose tolerance were selected for prospective study and to test the feasibility aspect of long-term intervention with an emphasis on life-style changes.Glucose tolerance was normalized in greater than 50% of subjects with impaired glucose tolerance, the accumulated incidence of diabetes was 10.6%, and more than 50% of the diabetic patients were in remission after a mean follow-up of 6 years. Blood pressure, lipids, and hyperinsulinaemia were reduced and early insulin responsiveness to glucose loading preserved. Improvement in glucose tolerance was correlated to weight reduction (r = 0.19, p less than 0.02) and increased fitness (r = 0.22, p less than 0.02). Treatment was safe, and mortality was low (in fact 33% lower than in the remainder of the cohort).A 5-year protocol, including an initial 6-months (randomised) pilot study, consisting of dietary treatment and/or increase of physical activity or training with annual check-ups, was completed by 90% of subjects. Body weight was reduced by 2.3-3.7% among participants, whereas values increased by 0.5-1.7% in non-intervened subjects with impaired glucose tolerance and in normal control subjects (p less than 0.0001); maximal oxygen uptake (ml.min-1.kg-1) was increased by 10-14% vs decreased by 5-9%, respectively (p less than 0.0001).
Explanation / Answer
A study was conducted in a group of early stage Type 2 DM patients (n=41) and in a group of patients with impaired glucose tolerance (n=181) to see if long-term lifestyle changes like diet and exercise can be helpful in controlling or preventing Type 2 diabetes. All the study participants were Malmo males within the age group of 47 to 49. The study showed that, in more than 50 percent of the subjects with impaired glucose tolerance, tolerance was back to normal with only 10 percent of them getting diabetes and among the diabetes patients, more than 50 percent had diminished severity of the disease. These positive results were seen mostly in those participants who had lost weight and had increased fitness. Conditions like high blood pressure, high lipids and hyperinsulinemia were also reduced in the test subjects. This study was conducted for 5 years which included dietary treatment, an increase of physical activity and annual check-ups and 90% of the subjects completed the study. After the completion of the study, overall the participants had reduced body weight and increased lung function compared to controls.
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