The below figure: shows eleven neurons in a petri with each synapse is indicated

Question

The below figure: shows eleven neurons in a petri with each synapse is indicated. For the sake of thils assignment, assume that the neurotransmitter listed is the only one that is released into the respective synapse. All synapses are excitatory (EPSP) and when the cholinergic neuron spikes, all others willalso spike. The cholinergic neuron has an electrode inserted into one of its dendrites which is used to create an EPSP that has enough magnitude to exceed threshold for an action potential. Several treatments will be applied to this petri dish and you are to indicate if there is activity at synapse A, B, C and D following treatment application and stimulation of the electrode. An"X" indicates no activity and a "V" indicates activity dish that comprise a circuit and the major neurotransmitter associated eleetroode Cholineic Dopaminergre Glutemiergic serotoner noredre ner^'c SYNAPSE No treatment 1. Reserpine 2. Curare 3. Nicotine 4. Ecto-5' nucleotidease 5. A drug that disrupts VGLUT 6. A drug that interferes with MAO 8. A drug that interferes with aromatic L-amino acid decarboxylase 9. Fenfluramine and curare 10. A drug that interferes with histidine decarboxylase

Explanation / Answer

SYNAPSE A

SEROTONERGIC

SYNAPSE B

HISTAMINERGIC

SYNAPSE C

OXYTOCIN

SYNAPSE D

NORAD

*Y stands for activity

* X stands for no activity

explanation:

All neurones are excitatory, and electrode is generating EPSP hence during no chemical application all are working

Reserpine blocks Vesicular mono amine transporters, therefore it blocks Noradrenaline, Serotonin,dopamine.

Curare blocks Acetyl choline, so whole branch below Ach including it will be paralysed.

Nicotene increases dopamine,serotonin,noradrenalin release

substance

SYNAPSE A

SEROTONERGIC

SYNAPSE B

HISTAMINERGIC

SYNAPSE C

OXYTOCIN

SYNAPSE D

NORAD

No treatment Y Y Y Y Reserpine X X Y X Curare X X X X Nicotene Y/increased Y Y/ Increased Y/increased

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