A patient develops a tumor on the left adrenal gland that hypersecretes aldoster

Question

A patient develops a tumor on the left adrenal gland that hypersecretes aldosterone. Click on all of the physiological changes and symptoms below that would result. Increased reabsorption of Na* in the distal nephron Increased mean arterial blood pressure Decreased activation of the sympathetic nervous system by baroreceptors Decreased excretion rate of filtered Na* Increased activation of the sympathetic nervous system by baroreceptors Increased excretion rate of filtered Nat Increased plasma angiotensin II concentration Increased plasma aldosterone concentration Decreased plasma renin concentration Increased plasma renin concentration Decreased reabsorption of Na* in the distal nephron Decreased mean arterial blood pressure Decreased plasma angiotensin Il concentration Decreased plasma aldosterone concentration

Explanation / Answer

Hyperaldosteronism leads to :

Increased arterial blood pressure--increased aldosterone leads to increased absoption of Na+ and water, increasing blood volume which leads to increase in blood pressure.

Increased re-absorption of Na+ in distal nephron--Tumor of left adrenal gland that hypersecretes aldosterone leads to increased increased Na+ and water absorption.

Decreased excretion rate of filtered Na+.

Increased plasma aldosterone concentration.

Decreased plasma angiotension II concentration--Plasma angiotension II concentration depends on Na+ levels, which is increased in hyperaldosteronism, thereby reducing plasma angiotension II concentration.

Decreased plasma renin concentration--Renin concentration is regulated by Angiotension I and thereby plasma angiotension II, if plasma angiotension II concentration is decreased, so renin automatically decreased in plasma

Increased activation of sympathetic nervous system by baroreceptors--Baroreceptors are found in the walls of large vessels, so increase in blood pressure leads to increased activity by baroreceptors.

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