A patient develops a tumor on the left adrenal gland that hypersecretes aldoster

Question

A patient develops a tumor on the left adrenal gland that hypersecretes aldosterone. Click on all of the physiological changes and symptoms below that would result

Increased excretion rate of filtered Na

Decreased reabsorption of Na in the distal nephron

Decreased mean arterial blood pressure

Increased plasma angiotensin II concentration

Increased plasma renin concentration

Decreased plasma aldosterone concentration

Decreased excretion rate of filtered Na

Increased reabsorption of Na in the distal nephron

Increased mean arterial blood pressure

Decreased plasma angiotensin II concentration

Decreased plasma renin concentration

Increased plasma aldosterone concentration

Explanation / Answer

.Tumour is increased growth of cell in number or mass.The mineralcorticoid is aldosterone and its secretion is not under the control of anterior pituitary,where it is secreted into blood by adrenal cortex (zona glomerulosa)stimulated by angiotensin II.It's function is to promote absorption of sodium and and excretion of potassium When a patient develops a tumour on the left adrenal gland results in excessive secretion of aldosterone in blood develops a disease called primary hyperaldosteronism or conn's syndrome due to benign tumour called adrenal adenoma . The varrious symptoms of conn's syndrome

1. increased mean arterial blood pressure because blood pressure raised where systolic blood pressured measured 140mmHg.

2 increased plasma aldosterone concentration

3.decreased plasma renin concentration ,both aldosterone and renin are measured by aclinical diagonstic test called saline suppression test and ambulatory salt loading test.High aldosterone to renin ratio indicates the presence of primary hyper aldosteronism

4.increased plasma angiotensin II concentration which regulates aldosterone secretion

5 .increased excretion of filterd Na ion due to hypernatremia Surgical removal of adenoma is the treatment

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