What is the approximate ratio of each ion (column 4)? Note that the ratio is mor

Question

What is the approximate ratio of each ion (column 4)? Note that the ratio is more important than the absolute values relative to Nernst.

Calculate the equilibrium potential for each ion.

Calculate the movement (if channels for each suddenly opened) based on a resting membrane potential
of -70 mV

Nernst Eion - 6l mV/Zion *Log ([ionlout/ [ion].) Note 61 mV-RT/F Resting Membrane Potential for a cell as defined below -70 mV llanm ECE (out) ICF (in) Ratio:Out/In Nernst E Permeability Movement Na 150 mM 15 mM 5 mM 150 mM 26 CI 98 mM 7 mM 45 Ca 2.4 mM .0001 mM 7?

Explanation / Answer

Sodium ion:

Ratio of out/in - (150/15) = 10

Nernst equation - 61 mV/Z log (out/in)

= 61/1 log (10)

= 61 (1)

= 61 mV

Movement - into the cell

Potassium ion:

Ratio of out/in - (5/150) = 0.03

Nernst equation 61 mV/Z log (out/in)

= 61/1 log (0.03)

= 61 (-1.52)

= -92.72 mV

Movement - out of the cell

Chloride ion:

Ratio of out/in - (98/7) = 14

Nernst equation - 61 mV/Z log (out/in)

= 61/1 log (14)

= -61 (1.146)

= -69.906

Movement - into the cell

Calcium ion:

Ratio of out/in - (2.4/0.0001) = 24000

Nernst equation - 61 mV/Z log (out/in)

= 61/2 log (24000)

= 30.5 (4.38)

= 133.59

Movement - into the cell

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