Dr. Ramos discussed how difficult it could be to treat infection in the brain an

Question

Dr. Ramos discussed how difficult it could be to treat infection in the brain and spinal cord because of how efficiently the blood-brain barrier protects vulnerable nervous tissues, even from lie-saving antibiotics. The barrier is mostly simple squamous endothelial cells, their basal laminae, and astrocytes. Which of the following statements is false with regard to how this thin layer of cells creates such and efficient barrier?

a. The endothelial cells contain more tight junctions than are found in the endothelial cells in capillary walls in other regions of the body.

b. extra tight junctions force molecules to pas between endothelial cells, which reduce the amount of substance entering the cell by endocytosis.

c. the combination of barrier endthelial cells, the extra tight junctions, and very selective barrier that is only a few cell layers thick leads to a limited ability to transport substances into and out of the cell.

d. Protein channels selectively allow for the transport of vital substances, such as glucose and amino cids that are unable to pass into the brain extracellular fluid without assistance.

Explanation / Answer

The blood brain barrier is a highly selective semipermeable membrane in tge brain. It is made up of endothelial cells which comprise tight junctions. The membrane only allow hydrophobic molecules and restrict hydrophylic molecules. BBB is permeable to glucose and amino acids. BBB contains endothelial cells that restricts the ability of molecules present in blood stream to pass through it.

So the answer is (B)

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