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'11 T-Mobile 12:18 PM 69%) Done image.pdf Copy Select All Highlight -13 of 13 38. (10 points) The following data was collected during an endocrine diagnostic analysis of the serum from an adult patient. Reference values for the normal population are shown What do the values tell you about the patient? Any obvious blood chemistry changes not shown you might expect? Can you suggest a treatment or medication if one is justified? Serum Hormone Values from Patient X and Reference Value Ranges Hormone Diagnostic or Basal Reference Value Ranges Patient X Adult Male Adult Female Estradiol (pM) 495 Testosterone (nM) 0.2 73-2.753 0.17-2.43 0.25-7.15 0.11-566 002-4.44 4-138 0.14-9.4 72-259 0.4-5.5 221-690 37-184 11-220 9.0-34.7 LH (IU/L) FSH (IUL PRL (nM) Thyroxine (nM) 12 1-8 0.09-0.81 72-176 04-5.5 221.690 0.2-144 c0.81 72-192 0.7-9.1 221-690 1.05 1 121 thCortisol (nM)1,3122 ACTH (M) 27.5 07-11 07.11 07-11 200 2.8 124 112 Insulin (pM) 34-138 34-138 34-138 on (pM) c17.2 GH (pM) IGF- (nM) 9-124 9-143 2-100 Fsh I L,H , esh.dial,TF?, !"d"cat. dat i..r 3 13Explanation / Answer
Cushing's syndrome is a hormonal disorder caused by prolonged exposure of the body's tissue to high levels of the hormone cortisol. Sometimes called hypercortisolism, Cushing's syndrome is relatively rare and most commonly affects adults aged 20 to 50. People who are obese and have type 2 diabetes, along with poorly controlled blood glucose also called blood sugar and high blood pressure.
Normally the production of cortisol follows a precise chain of events. First the hypothalamus a part of the brain sends corticotropin-releasing hormone to the pituitary gland. CRH causes the pituitary to secrete ACTH which stimulates the adrenal glands. When these glands receive the ACTH, they respond by releasing cortisol into the bloodstream.
Treatment depends on the specific reason for excess cortisol and may include surgery, radiation, chemotherapy or the use of cortisol-inhibiting drugs.
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