Cell 26.67/140To 0 Thick-skinned The disorder kthyoits results from a delective

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Cell 26.67/140To 0 Thick-skinned The disorder kthyoits results from a delective irtracelular peotein involved in keratin assemblage and maturation The defective gene s present in four to seven percent of the population and it is associated with several skin conditions, all of which are charactertzed by thickened and roughened skin in those with the severest form, the thickened epidennis cracks into plste-lke tragments creating the appexance of fish scales. Cese History Read the repont and answer all questions sleeved shirts and even turtle necks almost the entire year. Athough he enjoys soaking in his bathtub, he never goes to a pubc swimming pool All this modesty is because the skin over much of his body is dry. rough and looks lke fish scales known as ichthyosls (derived from the Greek word for fish Paul has a condition At biath, Pad looked lke any other newborn baby. Bul. by the age of three month it was obvous Something was different about his skon By fwo years, much of Paufs body was coveved with markedly thickened and scaly epidermis other organetles, thene is on internal skeletal structure to the cytoplasm of our cels. This internal protein skeleton provides strength to be funcfional Pat's stuation iustrates what happens when hings go wrong s condition lustrates the complex nature of the cytoplasm of our cels. Beyond the nucleus, the endoplasmic reticulu and all the and in some cases mobity to our cells. Bud like any systetyof strcthure and scatolding. it has to be assembled property Pre789 14 Next >

Explanation / Answer

Answer of questions no.2

•The defective fllaggrin gene occour in about 40% of the population.

Firstly filaggrin is a protein which help in role of skin barrier function.it work as a moisturizer for the skin ,as it hydrates the skin.

Icthyosis is a rare genetic disorder, due to which skin become very dry and fish like scaly appearance. This disease occur due the mutation in the gene passed from one of the parent to the child.

But sometimes ,both parents are normal but they are carrier of the defective gene. This defective gene filaggrin passes to the child and the child get inherit with this disorder.

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