Question 14 (2 points) A problem caused a patient\'s blood levels of insulin-lik

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Question 14 (2 points) A problem caused a patient's blood levels of insulin-like growth factor-1 (IGF-1) to increase What would you expect to happen to their blood levels of growth hormone (GH) and growth hormone releasing hormone (GHRH)? 1) increased GH and decreased GHRH 2) increased GH and increased GHRH 3) decreased GH and increased GHRH 4) decreased GH and decreased GHRH 18 Question 15 (2 points) A problem caused a patient's blood levels of growth hormone releasing hormone (GHRH) to decrease. What would you expect to happen to their blood levels of growth hormone (GH) and insulin-like growth factor-1 (IGF-1)? thing to Save

Explanation / Answer

the asnwer is 4. IGF-I has a negative-feedback eect on the secretion of GH. It directly acts on the somatotrophs to inhibit the stimulatory action of GHRH on GH secretion. IGF-I also inhibits GHRH secretion and stimulates
the secretion of somatostatin which is also known as GHIH (growth hormone inhibiting hormone). By stimulating IGF-I production, GH inhibits its own secretion.
IGF-1 decrease both GH and GHRH

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