4) Calculate the resting membrane potential using the appropriate information in

Question

4) Calculate the resting membrane potential using the appropriate information in the table belovw (consider all three ions: Na', K', and C). (4 points possible) Repeat your calculation from #4, but this time only consider Na+ and K+. answer here with your answer in #4 and with #3. Which ion(s) appear to have the greatest impact on resting membrane potential in a typical neuron? (5 points possible) 5) Compare your the K' ion equilibrium potential calculated in 6) During an action potential, the extracellular and intracellular concentrations of Na' and K actually change very little. Instead, the changes in membrane potential that occur during an action potential are explained by instantaneous changes in membrane permeability to Nat and K due to the opening and inactivation/closing of voltage-gated ion channels. must the relative permeability to Na* increase in order to depolarize/overshoot th the cell membrane to a peak of +30 mV (as occurs by the end of the rising phase of an action potential)? Assume all ion concentrations are not measurably changed, permeabilities to K' and Cl are still 1.00 and 0.45, respectively. Hint: you will need to use anti-In for this one... (3 points possible) e inside of Extracellular and intracellular iononcentrations and relative permeabilities for a hypothetical human neuron at 37°C. Ion Extracellular Na 144 Cl Intracellular Relative Concentration (mM) Concentration (mM) Permeability 14 143 7 0.04 1.00 0.45 100

Explanation / Answer

4.When the memberane conductance will increase for a particular ion,the membrane potential will obviously move to the Nernst potential. The Nernst potential is the potential which will balance the unequal concentration across the membrane of that ion. 5. The positive voltage inside the neuron will keep the higher concentration of positive sodium ions outside the cell.A large negative voltange will hold the positive K+ions inside the cell. It follows the rule opposites attract and similar charge repel each other.

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