6. Answer the following questions about the the thyroid gland (a) Describe the s

Question

6. Answer the following questions about the the thyroid gland (a) Describe the synthesis of thyroid hormone in the thyroid gland. In particular, what compounds are required to synthesize Ta/T4? What protein is required to transport T3/T4? (b) Next, describe regulation of thyroid hormone in the context of the hypothalamus-pituitary tripartite axis. (c) Hashimoto's disease is a form of primary hypothyroidism. In this disease, what would happen to the levels of (i) Thyroid Hormone, i) TSH, andi TRH. Justify your answer.

Explanation / Answer

6.aThyroxine which is T3 and triodothyronine wih is T3 are produced from the thyroid follicular cells within thyroid gland.It is a process which is regulated by the thyroid stimulating

hormonewhich is secreted by the anterior pitutary gland.

6b.the HPT axis determines the set point of the thyroid hormone production.the stimulation and synthesis and secretion of thyrotropin is done by the TRH.

T3 is identical to T4 but it has less iodine atom in a molecule.

tBG,TTR and albumin are the most important proteins required for the transport of T3 and T4.

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