Histone acetyltransferases (HATs) are capable of remodeling chromatin by adding

Question

Histone acetyltransferases (HATs) are capable of remodeling chromatin by adding acetyl groups to various lysine residues in histones that comprise the nucleosome. Following this modification, the lysine residue no longer has a positive charge. Which statement is true?

-Histones in general have a net negative charge that allow them to bind to DNA. Acetylation of histones, decreases their positive charge and strengthens the histone--DNA interaction -Histones in general have a net negative charge that allow them to bind to DNA. Acetylation of histones, decreases their positive charge and weakens the histone-DNA interaction. -Histones in general have a net positive charge that allow them to bind to DNA. Acetylation of histones, decreases their positive charge and weakens the histone-DNA interaction. -Histones in general have a net positive charge that allow them to bind to DNA. Acetylation of histones, decreases their positive charge and strengthens the histone-DNA interaction.

Explanation / Answer

Histones have net positive charge and acetyl have net negative charge therefore it allows to bind DNA to histone. Due to interaction between DNA and acetyl group the net positive charge on the histones get decreases and it losses the grip between DNA and histone interaction.

Hence option third is correct.

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