Histone deacetylase (HDAC) I and II are expressed in the heart in response to hy

Question

Histone deacetylase (HDAC) I and II are expressed in the heart in response to hypertension (high blood pressure). This results in the overexpression of specific heart growth factor proteins that cause pathological hypertrophy (overgrowth) of the heart muscles. It is known that histone acetyl transferases (HATs) do not modify the growth factor gene’s histones.From what you know about how HDACs function in gene regulation, you would predict that this overexpression is due to:

A) HDACs activating the growth factor genes by removing acyl groups from histones at the promoter

B) HDACs inactivating the growth factor genes removing acyl groups from histones at the promoter

C) HDACs activating a repressor of growth factor genes removing acyl groups from histones at the repressor’s promoter

D) HDACs inactivating a repressor of growth factor genes removing acyl groups from histones at the repressor’s promoter

The correct answer is D but I thought it was B. Could someone tell me why it was D and go through each choice and say why they are wrong?

Thank you!

Explanation / Answer

A) HDACs activating the growth factor genes by removing acyl groups from histones at the promoter ------> FALSE (deacetylation of histones decreases gene expression)

B) HDACs inactivating the growth factor genes removing acyl groups from histones at the promoter -------> FALSE ( It is known that histone acetyl transferases (HATs) do not modify the growth factor gene’s histones)

C) HDACs activating a repressor of growth factor genes removing acyl groups from histones at the repressor’s promoter ---------------> (deacetylation of histones decreases gene expression)

D) HDACs inactivating a repressor of growth factor genes removing acyl groups from histones at the repressor’s promoter -----------> TRUE

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