Critical Thinking Assignment 9: Mammalian Blood I. Polycythemia vera is a condit

Question

Critical Thinking Assignment 9: Mammalian Blood I. Polycythemia vera is a condition where there is an abnormal increase in (primarily) the number of red blood cells. For each of the following possible causes of Polycythemia vera, explain why each would result in an abnormally high concentration of red blood cells. (6 pts). Make sure your answer addresses whether or not more red blood cells are made and how. (i) Chronic myeloproliferative discase (form of leukemia) Example answer: Uncontrolled cell division due to disruption of the cell cycle results in large 's of RBC' (i) Living at high altitude The oxygen is lwer, eyth So mere red blood cels are mocde due to steps Is te d ative,Inou 01 (ii) Erythropoietin secreting tumor The secretng of erytwopoietm bnds No EPO receptus in lane marum to increase'ye of red blood cells in blood (iv) Decreased plasma volume

Explanation / Answer

(ii) living at high altitudes:

can develop polycythaemia. they produce more EPO (secondary erythrocytosis). so causes paraneoplastic, EPO tumors also. this all conditions arise when less oxygen is available.

(iii) erythropoietin secreting tumour:

Certain tumours can produce increased amounts of erythropoietin. The most common erythropoietin-secreting tumours are:

in some genetic disorder also increases the production of erythropoietin causes polycythaemia.

also, blood doping is a method to increase HB, more oxygen can be delivered, but it is illegal. that's why the athletes are advised to increase RBC by staying at higher altitudes.

(iv) decreased plasma volume:

Primary (LOW EPO): Reduced plasma volume= CONCENTRATED blood.

In some secondary polycythaemia, the haemoglobin of red blood cell count is abnormally high due to an increased concentration of blood. This can happen as a result of plasma volume loss from dehydration, severe vomiting or diarrhoea, or excessive sweating. Polycythaemia in these situations is called relative polycythaemia because the actual numbers of red blood cells are not abnormal.

people living in high altitudes may suffer from the risk of polycythaemia due to lesser O2 level.

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