20. Which of the following constitutes the critical survival cytokine for B cell

Question

20. Which of the following constitutes the critical survival cytokine for B cells in secondary lymphoid tissue? A. BAFF B. IL-7 C. IL-25 D. TNFo E. None of the above 21. The first immunoglobulin isotype produced during the course of a primary immune response contains which of the following heavy chains? A. y (Gamma) B. K (Kappa) C. 8 (Delta) D. H (Mu) E. None of the above 22. To which compartment in the body can long-lived plasma cells potentially be retained for the lifetime of the individual? A. Medullary cords of the lymph node B. Germinal center C. Bone marrow D. Red pulp of spleen E. None of the above

Explanation / Answer

Plasma cells are fully differentiated B-lymphocyte (white blood cell) which produces a single type of antibody. After formation in the bone marrow these cells goes to the germinal centre of lymph nodes for maturation and a fully mature B lymphocyte is mostly retained in the medullary cord of lymph node. Medullary cord is a portion of the medulla of the lymph node which contains lymphatic tissue and project into the medullary sinus. B cells and plasma cells are the main cell types found in the medullary cords.

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