What may occur to signal transmission in a presynaptic neuron after the synaptic

Question

What may occur to signal transmission in a presynaptic neuron after the synaptic cleft becomes loaded with a high concentration of the neurotransmitter serotonin (5-HT)?

A. Serotonin is reabsorbed into the axon terminal by the serotonin transporter (SERT) and is recycled - i.e., it can be secreted again during a subsequent action potential.

B. Serotonin readily binds to post-synaptic serotonin receptors, activating signal transmission.

C. Serotonin binds to pre-synaptic serotonin receptors, downregulating further serotonin release

D. Some serotonin begins to be metabolized in the axon by mitochondria into 5-HIAA.

E. All of the above.

Explanation / Answer

Ans. Option E all of the above

All the below option ate correct and well explained

Serotonin is reabsorbed into the axon terminal by the serotonin transporter (SERT) and is recycled - i.e., it can be secreted again during a subsequent action potential.

B. Serotonin readily binds to post-synaptic serotonin receptors, activating signal transmission.

C. Serotonin binds to pre-synaptic serotonin receptors, downregulating further serotonin release

D. Some serotonin begins to be metabolized in the axon by mitochondria into 5-HIAA.

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