Immune System Case Study 1.) You are a physician’s assistant working in the area

Question

Immune System Case Study

1.) You are a physician’s assistant working in the area of immunology.  You have a unique patient who came in demonstrating symptoms that you have never seen before. The first thing you discover from talking with the patient is that they are becoming sick much more easily than usual, particular with relapses of sicknesses they already have had. Upon examination you notice that the patient’s ability to activate T cells of various types, especially cytotoxic and helper T cells has been dramatically reduced. As any good physician’s assistant would do you immediately perform a blood cell count and notice a dramatic reduction in macrophages, but no change in T or B cell lymphocyte number in their blood or changes to visible T or B cell health. Because you are a very astute PA you immediately come to the conclusion that….

2.) If we assume this patient’s problem is mediated by a new form of virus tell me how this new virus is likely affecting this individual. Using approximately three or four sentences pretend you are explaining this disease directly to the patient involved so that this individual can understand what you think is occurring starting with the virus infection to why they are becoming so easily infected. For example, explain what the likely target of this virus is and why this virus is altering activity of helper and cytotoxic T cells?

Explanation / Answer

1). Myeloid leukemia - Decreased macrophage count, reduced ability to differentiate T cells, and normal lymphocyte number indicate acute myeloid leukemia.

However, further examination should include WBC count and morpholocal examination, abnormal WBCs with prominent nucleolus   - Suggests Acute myeloid leukemia (AML)

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