New Research in RNA May Help Diagnose Lung Cancer Researchers, Qingchun Lu, Shan

Question

New Research in RNA May Help Diagnose Lung Cancer Researchers, Qingchun Lu, Shan Shan, Yanyan Li, et. al., in Shanghai, China experimented with regulating and inhibiting a specific RNA molecule to determine its effects on cancer. Their findings, published in The FASEB Journal on February 21, 2018, concluded that long non-coding RNA contributes to the progression of non-small cell Lung Cancer. This information could lead to possible breakthrough techniques to diagnose and treat lung cancer. This monumental discovery comes at a time when Lung Cancer is considered the most deadly among all cancer-related deaths. Non-small cell lung cancer is the most common type of lung cancer that is diagnosed. Specifically, 85 percent of the disease is non-small cell lung cancer (NSCLC). Recent studies have found that regulatory RNA play a role in cancer development, stem cell differentiation, and chemotherapy development. Studies revealed that the expression of a small nucleolar host gene 1, SNHG1, is a specific type of long non-coding RNA that promotes cell proliferation, migration, and invasion. Research suggests that SNHG1 may cause progression in other cancers as well. Although the specific mechanisms are currently in progress, the SNHG1 may be significant in NSCLC development. As a result, the study found that SNHGI factors were increased in healthy tissue. To further examine this activity, mice trials were used by evaluating tumor volume weekly. The results of the mice trials revealed the decrease level of SNHG1 in tumor measurements. The results of the study suggest overexpression of SNHG1 in NSCLC, which indicate that SNHG1 is most likely a cancer promoter in NSCLC. The study currently stands in momentous position in that it paved the way for discovering the exact mechanism of SNHG1 in promoting NSCLC. Although it is not complete yet, the research on mechanism ultimately would lead to potential therapeutics to target lung cancer by finding methods to block the effect of SNHG1 in tumor cell proliferation and motility.

Explanation / Answer

Answer-as non small cell carcinoma are the most common lung cancer.as it is suggested that SNHG1 is tumor prolifeting gene.it's inhibition is desirable to control non small cell carcinoma of the lung.but we have to look other aspects also like paraneoplastic syndrome and metastasis associated with the non small cell carcinoma of lung.

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