Question 3. You identify neurons that are part of a central pattern generator (C

Question

Question 3. You identify neurons that are part of a central pattern generator (CPG) a. Assume the CPG uses the pacemaker/follower model. If you could magically make the synaptic connection from the pacemaker cell to the follower cell excitatory instead of inhibitory how would the firing pattern of the follower cell change? Would it still show rhythmic activity? b. Assume the CPG uses the reciprocal inhibition model. How would the firing patterns of the cells change if both cells no longer showed adaptation (decrease in firing rate over time)? Would they still show rhythmic activity? Walk

Explanation / Answer

The cellular and ionic mechanisms that generate the rhythm in central pattern generator (CPG) networks for simple movements are not well understood. Using vertebrate locomotion, respiration and mastication as examples we can describe four main principles of rhythmogenesis.

1) rhythmogenic ionic currents underlie all CPG networks regardless of whether they are driven by a network pacemaker or an endogenous pacemaker neuron kernal.

2) fast synaptic transmission often evokes slow currents that can affect cycle frequency.

3) they are likely to be multiple and redundant mechanisms for rhythmogenesis in any essential CPG network.

4) neuroglial cells may participate in CPG network function.

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