lIOn, ilBugH he heeds turther information to confirm the diagnosis. What led him

Question

lIOn, ilBugH he heeds turther information to confirm the diagnosis. What led him to conclude that the patient has a bacterial infection, and why 2 A common consequence of many cancer chemotherapy drugs is destruction of bone marrow cells. This leads to a decrease in the number of circulating erythrocytes and leukocytes, resulting in conditions called anemia and leukopenia, respectively. Predict the consequences of anemia and leukopenia, considering the function of these types of cells. The poison ricin, derived from the castor bean plant, interferes with protein synthesis. Which formed elementsc blood would ricin affect directly? Are there any mature formed elements in the blood that ricin would not affec Explain. (Hint: Where does the first part of protein synthesis take place?) is of thue bloud can he deAned as

Explanation / Answer

Chemotherapy drugs mainly acts by inhibiting synthsisy of the DNA by the rapidly dividing cells in the body like cancer cells.

So during inhibition of rapidly dividing malignant cells, these drugs also inhibiting the division of normal physiological rapidly dividing normal bone marrow blast cells mainly the haematopoietic stem cells, there fore development of the deficiency of RBC, WBC platelets, producing condition of pancytopenia.

Deficiency of rbc cell mass lead to development of the ANEMIA, due to which there is decreased o2 carrying capacity of the blood and hypoxia develop, also their is decreased circulation volume of blood lead to develop hyperdynamic circulation in the body, patient become lethargic, weak, loss of appetite are common symptoms.

Due to deficiency of wbc lead to developing leukaemia

Decreased wbc count lead to increased succeptibility to infection, and immunity of patients become decline, patient become more prone to acquire multiple disease,lead to fever, headache, generalized body weaknesses.

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