Transplantation involves the transfer of tissues or organs from one person to an

Question

Transplantation involves the transfer of tissues or organs from one person to another person. Some transplantation procedures can involve the transfer of tissue between different sites on the same individual’s body. Consider the case of the transplantation of a liver from one person to an unrelated recipient who has liver failure. Although any two humans are more than 99% genetically identical, they do have genetic differences that might lead to a reaction in which the recipient’s immune system attacks the donor tissue. This is called transplant rejection.

Although we have not yet covered the immunologic basis of transplant rejection, consider what you have learned about the immune system so far in this course. What scenario, below, is most likely to cause transplant rejection?

A. Antigen receptors on recipient T cells will bind to peptide-MHC complexes in donor tissue and initiate an adaptive response that causes transplant rejection.

B. Toll-like receptors on recipient DCs will bind to peptide-MHC complexes in donor tissue and initiate an innate response that causes transplant rejection.

C. Antigen receptors on recipient T cells will bind to PAMPs in donor tissue and initiate an adaptive response that causes transplant rejection.

D. Toll-like receptors on recipient DCs will bind to PAMPs in donor tissue and initiate an innate response that causes transplant rejection.

Explanation / Answer

Answer should be A.

As we know that, T cell will recognize and binds to MHC 2 complex,present om the graft tissue and gets activated and produces more clones.

The response will be apoptosis of the graft tissue.

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