de Langhe E, Vande Velde G, Hostens J, et al. Quantification of lung fibrosis an
ID: 3521748 • Letter: D
Question
de Langhe E, Vande Velde G, Hostens J, et al. Quantification of lung fibrosis and emphysema in mice using automated micro-computed tomography. PLoS ONE. 2012;7:e43123. https://doi.org/10.1371/journal.pone.0043123This article details a method of measuring lung volumes in disease states, using computerized tomography (similar to a CAT scan). Consider the following questions: why is the measurement of lung volume important to the diagnosis of both emphysema and lung fibrosis? Why is the measurement of collagen (hydroxyproline content) important in determining disease states in the lung? How would collagen content differ in fibrosis and emphysema? Finally, why do you think the authors needed to perform histologic examination of the lung tissue they had measured when the animals were alive?
de Langhe E, Vande Velde G, Hostens J, et al. Quantification of lung fibrosis and emphysema in mice using automated micro-computed tomography. PLoS ONE. 2012;7:e43123. https://doi.org/10.1371/journal.pone.0043123
This article details a method of measuring lung volumes in disease states, using computerized tomography (similar to a CAT scan). Consider the following questions: why is the measurement of lung volume important to the diagnosis of both emphysema and lung fibrosis? Why is the measurement of collagen (hydroxyproline content) important in determining disease states in the lung? How would collagen content differ in fibrosis and emphysema? Finally, why do you think the authors needed to perform histologic examination of the lung tissue they had measured when the animals were alive?
de Langhe E, Vande Velde G, Hostens J, et al. Quantification of lung fibrosis and emphysema in mice using automated micro-computed tomography. PLoS ONE. 2012;7:e43123. https://doi.org/10.1371/journal.pone.0043123
This article details a method of measuring lung volumes in disease states, using computerized tomography (similar to a CAT scan). Consider the following questions: why is the measurement of lung volume important to the diagnosis of both emphysema and lung fibrosis? Why is the measurement of collagen (hydroxyproline content) important in determining disease states in the lung? How would collagen content differ in fibrosis and emphysema? Finally, why do you think the authors needed to perform histologic examination of the lung tissue they had measured when the animals were alive?
Explanation / Answer
1.Lung volumes finding in emphysema and lung fibrosis are-
In emphysema , the lung compliance will increse, these is because the ability of the elastic recoil of the lung is lost in emphysema . The expiartory volumes will decrease , therefore on pulmonary function test, the FEV and FVC will decrease, and the FEV/FVC ratio will also decrease.
In lung fibrosis , both expiratory and inspiratory volumes are lowered so,Vital capacity(VC), functional residual capacity(FRC), total lung capacity(TLC), and forced vital capacity (FVC) all are reduced.
2.During lung emphysema , it is the elastin that is decreased , not the collagen, which causes the loss of elasticity.
During lung fibrosis, there is increase in the collagen type 1 , which causes extensive fire formation, ultimately leading to fibrosis.
3. Histological examination of emphysema will reveal enlarged air spaces, with destructed alveolar walls .
Histological examination of lung fibrosis will reveal closed air spaces, or narrow lumen.
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