4 The disease bullous pemphigoid 4 The s and dermas id results in the destructio

Question

4 The disease bullous pemphigoid 4 The s and dermas id results in the destruction of proteins within the basement nhe an efective How would this likely impact the epidermis? Would the skin that hold the e barrier lands with this disease? 5 Would you have expected to have found more Meissner's corpuscles and Merkel dises on the palm or on the posterior shoulder? Why? 6 In which areas of the body would you expect to find the most Merkel discs and tactile corpuscles? Why? 7 Why do you have unique markings on your fingers, toes, palms, and soles but not on any other part of the body Why do you leave behind fingerprints when you touch certain surfaces? nnd Phusiolopy Laboratory

Explanation / Answer

4. ANS: Bullous pemphigoid affect on epidermis:

Answer: Bullous pemphigoid is an autoimmune disease. it destroy  hemidesmosomes causing formation of subepidermal blisters.

Explanation: The target protein in this disease is BP180. These proteins are within the NC16A domain of the collagen XVII which are associated with  hemidesmosomes, structures that ensure the epidermal keratinocyte cells stick to the dermis to make a waterproof seal.

This leads to destruction of  hemidesmosomes and cause formation of subepidermal blisters.

Would the skin be an effective barrier to this disease?

Answer: No

Explanation: The skin is weakened and prone to secondary infections by staphylococcus and this is why one of the management of this disease is the use of antibiotics to manage secondary infections.

5. ANS: The Meissner's corpuscles are mechanoreceptors found in deeper layers of skin and it can respond to touch or pressure. Both of them are found in skin areas that are very sensitive to pressure and touch. Smaller and denser the receptive field, greater is the capacity to process the stimulus. Since fingertips are smaller in area and sensitive too, the merkel disks and meissner's corpuscles are found to be clustered in the skin beneath the fingertips.

6. ANS: The fingertips, lips, and face have the most fine touch receptors due to their functions of differentiating shape,texture, and so on.

7. ANS: The dermal papillae in these areas are extensiveand they indent the overlying epidermis, creating epidermalridges that enhance for gripping ability.Sweat pores open at the top of the ridges, causing one to leave behindfingerprints.

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