7. You are interested in how proteins are imported into and eported out of the n

Question

7. You are interested in how proteins are imported into and eported out of the nucleus. For your experiment you use several mutant cell lines or treat normal cells with abnormal conditions. You examine 2 different proteins - protein A is 100 kD and protein is 25 kD. Both proteins have both an NLS and an NES. Neither NLS or NES is ever masked.

d) In Mutant 3 you can inactivate all importins instantly so that they have none of their normal functions. You induce this mutant to start translating protein B and inactivate importins simultaneously. Whre will protein B be found in thse cells? EXPLAIN

Explanation / Answer

protein B would be associated with synaptosomes since proteins less than 40 kD would be associated with this

the protein may be

Ran is a small 25 kDa protein that is involved in transport into and out of the cell ... Ran cycle;  Role in nuclear transport during interphase;  Role in ... Inside the nucleus, RanGTP binds to importin and releases the import cargo.

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