When glutamate + malate is used instead of succinate, a big difference was found

Question

When glutamate + malate is used instead of succinate, a big difference was found fig (b). Addittion of atepnin had NO EFFECT on the rate of O2 consuption. What does this suggest about the mode of action of atpenin?

2. Atpenin is a relatively new antifungal antibiotic produced by Penicillium. In order to investigate its mode of action the following experiments were preformed: A suspension of freshly-prepared mitochondria in phosphate buffer was incubated with various compounds and O2 consumption, measured with an oxygen electrode:

Explanation / Answer

Atpenin inhibit production of oxygen and increase the demand for ATP derived from ADP by activating ATP dependent potassium channels in mitochiondria.

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