eal 0612-01 Human Physiol. Facebook Chegg Tutors IOnline T... 0350-01 Cell Biolo
ID: 37563 • Letter: E
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eal 0612-01 Human Physiol. Facebook Chegg Tutors IOnline T... 0350-01 Cell Biology S... https://ilearn.sfsu.edu/a How could you try to pr Favorites 8. The following diagram lists different classes of mutants found in the temperature sensitive screen for defective secretion. Red dots represent proteins that are normally secreted, but accumulate in different organelles when proteins in that class are mutated. Each of these classes includes many mutant proteins that function at similar steps in the secretory pathway to cause accumulation in the same organelle Class A Class B Class C Class E Class D ER Golg O O O O Fate of Normal Accumulation Accumulation Accumulation Accumulation Accumulation secreted secretion in the cytoso n rough ER n ER-to-Golgi n Golgi in secretory proteins transport vesicles vesicles Defective Budding of Fusion of Transport Transport from Transport function into the ER vesicles from transport vesicles from Golgi to secretory vesicles to cell surface the rough ER with Golgi secretory vesicles Please circle which class the following mutant proteins would belong to Mutant Class Mutant protein defect A COPII coat protein which isn't recruited by Sarl-GTP A B C D E A t-SNARE on the plasma membrane unable to bind v-SNAREs A B C D E A signal recognition particle unable to bind to ribosomes A B C D E A v SNARF on COPII coated vesicles unable to bind t-SNARFs A B C D FExplanation / Answer
A COPII coat protein which isnt recruited by Sar1-GTP = A
A t-SNARE on the plasma membrane unable to bind v-SNAREs = C
A signal recognition particle unable to bind to ribosomes = A
A v-SNARE on COPII coated vesicles unable to bind to t-SNAREs = E
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