REQUIRED: The tumor suppressor gene p53 is involved in sensing DNA damage and pr

Question

REQUIRED: The tumor suppressor gene p53 is involved in sensing DNA damage and preventing cell replication if the damage is extensive. Below is a partial sequence of the p53 gene. In one particular portion of this sequence, a simple transition can cause a nonsense point mutation. Transcribe and translate the given DNA sequence and clearly indicate what mutation would be required and where it would have to occur. What effect would you expect this transition to have on the organism??s fitness, and why?

Explanation / Answer

Given DNA sequence

3

Given DNA sequence

3

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