You want to test whether a particular allele of the ?-interferon gene (the a3 al

Question

You want to test whether a particular allele of the ?-interferon gene (the a3 allele) is responsible for an immune deficiency disease.  Using an assay for a restriction site present in the a3 allele and absent in other ?-interferon alleles, you have mapped the inheritance of the a3 allele and the disease phenotype in a large number of affected families. You find that the map distance between the ?-interferon gene and the disease phenotype is 2 cM. (In other words, in 2% of cases, children inherit the disease allele without inheriting the a3 allele.)  Which one of the following conclusions can you make from these results?

A) The disease is caused by mutations in a gene that is linked to the ?-interferon gene.

B) The disease does not have a genetic basis.

C) The disease is caused by the a3 allele of ?-interferon.

D) The disease is caused by mutations in a gene unlinked to the ?-interferon gene.

E) The disease is caused by mutations in the ?-interferon gene, but not the a3 allele.

Explanation / Answer

Answer:

Option: C (Because the a3 allele is responsible for an immune deficiency disease)

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