Chloramphenicol is an antibiotic that specifically binds 23s rRNA on the ribosom
ID: 40645 • Letter: C
Question
Chloramphenicol is an antibiotic that specifically binds 23s rRNA on the ribosome in E. coli. When bacteria are exposed to this antibiotic: (select all that apply)
a.)
no initiation of translation can occur because the initiation factors are blocked from binding the small subunit of the ribosome
termination of translation is inhibited and the polypeptide is longer than the gene sequence specified
amino acids on the tRNAs in the ribosome cannot be joined together by peptide bonds
transcription will be initiated but will halt prematurely
the cells cannot translate proteins and they will die
no initiation of translation can occur because the initiation factors are blocked from binding the small subunit of the ribosome
b.)termination of translation is inhibited and the polypeptide is longer than the gene sequence specified
c.)amino acids on the tRNAs in the ribosome cannot be joined together by peptide bonds
d.)transcription will be initiated but will halt prematurely
e.)the cells cannot translate proteins and they will die
Explanation / Answer
Chloramphenicol is an antimetabolite drug that bind to ribosomal sub unit and inhibit protein synthesis. Choramphenicol is bacteriostatic, not bactericidal. The following options are correct.
a. no initiation of translation can occur because the initiation factors are blocked from binding the small subunit of the ribosome.
d. transcription will be initiated but will halt prematurely.
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