8) Which of the following is indicative of estradiol acting through a nongenomic

Question

8) Which of the following is indicative of estradiol acting through a nongenomic mechanism? A) The upregulation of progesterone receptors B) The inability of PPT to induce an increase in the intracellular Ca+2 C) The ability to increase the intracellular Ca+2 with E-6-BSA D) The ability of ICI to block the rapid intracellular increase of Ca+2 E) Both C and D 9) Estradiol increases progesterone levels in which brain regions of the post-menopausal rat? A) hypothalamus B) cortex C) cerebellum D) All of the above E) None of the above 10) Which of the following responds to estrogenic stimulation with an increase in progesterone levels? A) Postpubertal astrocytes B) Hypothalamus of a menopausal female rat C) Hypothalamus of a male rat D) Neonatal hypothalamic astrocytes E) Both A and D

Explanation / Answer

Answer:

8) C) the ability to increase the intracellular ca+2

Both estrogens and progesterone are transported in the blood bound mainly with plasma albumin which requires calcium and with specific estrogen- and progesterone binding globulins.The binding between these hormones and the plasma proteins is loose enough that they are rapidly released to the tissues over a period of 30 minutes or so.

9) D) All the above

The levels increase in the brain and adipose tissue

10) B) Hypothalamaus of a female rat

The hypothalamic needs to be activated for maximal levels of sexual receptivity in female rats (Pfaff and McEwen, 1983).

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