Compound \"K\" is the ultimate product of a linear metabolic pathway consisting
ID: 42672 • Letter: C
Question
Compound "K" is the ultimate product of a linear metabolic pathway consisting often (1-10) enzymatically catalyzed reactions as shown below. Complete the following description. If "K" inhibits activity of enzyme "5", then enzyme "5" is under_control. If enzyme "3" becomes activated in response to activity of protein kinase A only when compound "A" is present, then enzyme "3" is under_control. If enzyme "2" is only expressed in the presence of high concentrations of "A," then enzyme "2" is under_control. If all of these are true, high concentrations of "_" will decrease the flux through the pathway.Explanation / Answer
If 'K' inhibits activity of enzyme "5", then the enzyme "5" is under allosteric control. If enzyme "3" becomes activated in response to activity of protein kinase A only when compound "A" is present, then the enzyme "3" is under genetic control. If enzyme "2" is only expressed in the presence of high concentrations of "A" then enzyme "2" is under genetic control. If all of these are true, high concentrations of "K" will decrease the flux through the pathway.
The compound K is ultimate product and inhibits the activity of enzyme 5 by allosteric regulation by binding to its active site. The protein kinase A activates enzyme 3 to continue the pathway and high concentration of A is required for the activity of enzyme 2. Hence enzymes 3 and 2 are under genetic control. If the concentration of K is more then it may bind to enzyme 5 to inhibit its activity by allosteric regulation, hence the high concentration of K decreases the flux through pathway.
The option 1 is correct.
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